Important Safety Information for Wegovy® (semaglutide)

Atlas HRT safety summary derived from the Wegovy® Prescribing Information and Medication Guide revised 06/2026. Last reviewed September 11, 2026.

What is the FDA-approved use of Wegovy®?

Wegovy® injection is a prescription medicine used with a reduced-calorie diet and increased physical activity to: reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight.

help adults and children aged 12 years and older with obesity, or some adults with excess weight (overweight) who also have weight-related medical problems to lose weight and keep the weight off.

treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.

Wegovy® tablets are a prescription medicine used with a reduced-calorie diet and increased physical activity to: reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight; help adults with obesity, or some adults with excess weight (overweight) who also have weight-related medical problems to lose weight and keep the weight off.

Wegovy® contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines.

It is not known if Wegovy® injection is safe and effective: to reduce the risk of major cardiovascular events (death, heart attack, or stroke) in people under 18 years; to help children under 12 years of age lose weight and keep the weight off; for the treatment of MASH in people under 18 years of age.

It is not known if Wegovy® tablets are safe and effective for use in people under 18 years of age.

Wegovy® injection and Wegovy® tablets share one Prescribing Information and one Medication Guide, and this page follows that combined labeling.

Do not use Wegovy® if:

• you or any of your family have ever had a type of thyroid cancer called MTC or if you have an endocrine system condition called MEN 2.
• you have had a serious allergic reaction to semaglutide or any of the ingredients in Wegovy® injection or Wegovy® tablets.

Before using Wegovy®, tell your healthcare provider if you have any other medical conditions, including if you:

• have or have had problems with your pancreas or kidneys.
• have type 2 diabetes and a history of diabetic retinopathy.
• are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation).

Tell your healthcare provider about all the medicines you take

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Wegovy® may affect the way some medicines work and some medicines may affect the way Wegovy® works. Tell your healthcare provider if you are taking other medicines to treat diabetes, including sulfonylureas or insulin. Wegovy® slows stomach emptying and can affect medicines that need to pass through the stomach quickly.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the most serious side effects to watch for?

Wegovy® may cause serious side effects, including:

• inflammation of your pancreas (pancreatitis). Stop using Wegovy® and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. Sometimes you may feel the pain from your abdomen to your back.
• gallbladder problems. Wegovy® may cause gallbladder problems including gallstones. Some gallbladder problems need surgery. Call your healthcare provider if you have any of the following symptoms: pain in your upper stomach (abdomen), yellowing of skin or eyes (jaundice), fever, clay-colored stools.
• increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines to treat type 2 diabetes mellitus such as an insulin or a sulfonylureas. Low blood sugar in patients with type 2 diabetes who receive Wegovy® can be both a serious and common side effect. Talk to your healthcare provider about how to recognize and treat low blood sugar. You should check your blood sugar before you start taking Wegovy® and while you take Wegovy®. Signs and symptoms of low blood sugar may include: dizziness or light-headedness, sweating, shakiness, blurred vision, slurred speech, weakness, anxiety, hunger, headache, irritability or mood changes, confusion or drowsiness, fast heartbeat, feeling jittery.
• dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.
• severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Wegovy®. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
• serious allergic reactions. Stop using Wegovy® and get medical help right away, if you have any symptoms of a serious allergic reaction including: swelling of your face, lips, tongue or throat, severe rash or itching, very rapid heartbeat, problems breathing or swallowing, fainting or feeling dizzy.
• change in vision in people with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Wegovy®.
• increased heart rate. Wegovy® can increase your heart rate while you are at rest. Your healthcare provider should check your heart rate while you take Wegovy®. Tell your healthcare provider if you feel your heart racing or pounding in your chest and it lasts for several minutes.
• food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Wegovy® may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Wegovy® before you are scheduled to have surgery or other procedures.

Do not share your pen, Wegovy FlexTouch or needles with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.

What are the most common side effects?

The most common side effects of Wegovy® in adults or children aged 12 years and older may include: nausea; stomach (abdomen) pain; dizziness; gas; diarrhea; changes in skin sensations; feeling bloated; vomiting; headache; belching; stomach flu; constipation; tiredness (fatigue); upset stomach; low blood sugar in people with type 2 diabetes; heartburn; hair loss.

Talk to your healthcare provider about any side effect that bothers you or does not go away. These are not all the possible side effects of Wegovy®.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1‑800‑FDA‑1088.

Pregnancy and breastfeeding

Before using Wegovy®, tell your healthcare provider if you:

• are pregnant or plan to become pregnant. Wegovy® may harm your unborn baby. You should stop using Wegovy® 2 months before you plan to become pregnant.
• Pregnancy Exposure Registry: There is a pregnancy exposure registry for women who use Wegovy® during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry or you may contact Novo Nordisk at 1-877-390-2760 or www.wegovypregnancyregistry.com.
• are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with Wegovy® tablets. It is not known if Wegovy® when received through an injection passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Wegovy®.